Metaberine™ | Bio-Optimized Berberine for Metabolic Health

Metaberine

Bioavailable Berberine for Metabolic Health & GLP-1 Support

Metaberine™ – A Bio-Optimized Berberine Powered by BioSOLVE Technology, developed to support metabolic health, GLP-1 pathways, blood sugar balance, insulin sensitivity, and weight management with superior absorption.

Bioavailability

37×

Higher Cmax

200mg

Daily Dose

100% Natural & Vegan

Non-GMO, Clean Label

Clinically Proven

Randomised Double Blind Trial

GMP Certified

USFDA Registered Facility

Fastest Absorption

Tmax in just 30 Minutes

Gastric Friendly

No GI Discomfort

23%

Average increase in
GLP-1 secretion

The Ingredient

Bio-Optimized Berberine for True Metabolic Health

Metaberine™ is an advanced, clinically proven Berberine ingredient formulated with Zeus Hygia’s proprietary BioSOLVE® technology—a 100% aqueous, eco-friendly green process that produces a highly uniform, porous powder with dramatically improved solubility and bioavailability.

Unlike conventional berberine extracts with less than 2% absorption, Metaberine™ achieves 9× higher bioavailability at just 200 mg/day versus the 500–1500 mg typically required—reducing dosage burden and eliminating gastric discomfort.

By modulating GLP-1 activity, activating the AMPK pathway, and supporting healthy lipid profiles, Metaberine™ delivers a comprehensive, natural alternative to expensive GLP-1 therapies for metabolic wellness and weight management.

“Metaberine™  is the most effective and thoroughly researched metabolic support available at the lowest daily dosage.”

— Dr. Arunkanth Krishnakumar, Co-founder & CEO, Zeus Hygia

The Science

Pharmacokinetic Superiority Proven

In a randomised, double-blind, placebo-controlled crossover trial with 36 participants, Metaberine™ demonstrated unmatched absorption and clinical outcomes versus standard berberine extract.

Clinical Outcomes — 14-Day Trial

36 participants · Double-blind · Placebo-controlled · Crossover design

Reduction in fasting blood glucose levels

Decrease in post-prandial glucose spikes

Increase in GLP-1 secretion for appetite & weight control

Reduction in LDL cholesterol levels

Improvement in total cholesterol for a healthier lipid profile

Recommended Daily Dose

200 mg

vs 500–1500 mg
standard berberine

metaberine_metabolic health

Watch & Learn

See Metaberine™
in Action

Discover how Zeus Hygia’s proprietary BioSOLVE® technology transforms berberine bioavailability—and why Metaberine® is redefining metabolic health support for the nutraceutical industry.

Applications

Flexible Formulation Formats

Metaberine™  integrates seamlessly across a wide range of product types, enabling B2B partners to launch innovative metabolic health solutions.

Manufacturing

Purity, Safety & Excellence

Produced in a GMP-certified and USFDA-registered facility aligned with ISO 9001:2015 standards—Metaberine™  exemplifies manufacturing excellence and quality assurance at every stage.

metaberine_Manufacturing_zeushygia

BRANDS POWERED BY METABERINE™

Trusted by Innovative Brands

Discover how leading brands are leveraging Metaberine™, our clinically studied and highly bioavailable berberine ingredient, to create differentiated products for blood sugar support, weight management, and metabolic wellness.

NUTRITUNES

Metabovia_Metaberine_Zeushygia

GATACA

BioSolve Berberine_Metaberine_Zeushygia

OAK AND ZEN

oak and zen_pcos support_metaberine_zeushygia

ZYRO LIFE

FAQ

Frequently Asked Questions

What is Metaberine™ and how does it support metabolic health?

Metaberine™ is an advanced, clinically proven Berberine ingredient formulated with proprietary BioSOLVE® technology. It supports metabolic pathways by activating the AMPK enzyme, improving insulin sensitivity, and enhancing lipid metabolism—delivering superior results at just 200 mg/day.

Can Metaberine™ help in weight management and fat metabolism?

Yes. Metaberine™ aids weight management by supporting fat metabolism, reducing cravings via GLP-1 modulation, and improving energy balance—helping the body utilize nutrients more efficiently.

Is Metaberine™ suitable for PCOS or metabolic syndrome?

Absolutely. Metaberine™ supports hormonal balance, improves insulin response, and promotes metabolic stability—making it particularly beneficial for individuals managing PCOS or metabolic disorders where insulin resistance is a key factor.

How does Metaberine™ improve insulin sensitivity and blood sugar control?

Metaberine™ enhances insulin sensitivity and supports balanced glucose levels by activating both AMPK and GLP-1 pathways, promoting efficient sugar uptake and metabolism at the cellular level for measurable clinical outcomes.

What makes Metaberine™ different from standard Berberine extract?

Unlike regular extracts with less than 2% absorption, Metaberine™ offers 9× higher bioavailability, 37× higher Cmax, and a Tmax of just 30 minutes versus 8 hours—delivering clinically proven results at a fraction of the standard dosage.

Is Metaberine™ safe and well-tolerated for daily use?

Metaberine™ is pharmacokinetically tested, GMP certified, and well-tolerated at 200 mg/day with no gastric irritation—addressing the most common side effect reported with high-dose conventional berberine supplements.

Why Metaberine™ is better than Liposomal Berberine ?

Metaberine® doesn’t just improve berberine’s absorption it provides a clinically validated, formulation-friendly, and cost-effective solution that enables brands to deliver the benefits of berberine at lower dosages without the manufacturing challenges often associated with liposomal systems like stability issues, lipid to active ratio, uniformity & flowability

metabolic health_metaberine_zeushygia

Partner with Zeus Hygia

Bring Metaberine™  to your next metabolic health product. We support B2B partners across pharma, nutraceuticals, OTC, and functional food markets globally.

Approvals & Accreditations

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