Metaberine™
Bioavailable Berberine for Metabolic Health & GLP-1 Support
Metaberine™ – A Bio-Optimized Berberine Powered by BioSOLVE Technology, developed to support metabolic health, GLP-1 pathways, blood sugar balance, insulin sensitivity, and weight management with superior absorption.
9×
Bioavailability
37×
Higher Cmax
200mg
Daily Dose
100% Natural & Vegan
Non-GMO, Clean Label
Clinically Proven
Randomised Double Blind Trial
GMP Certified
USFDA Registered Facility
Fastest Absorption
Tmax in just 30 Minutes
Gastric Friendly
No GI Discomfort
23%
Average increase in
GLP-1 secretion
The Ingredient
Bio-Optimized Berberine for True Metabolic Health
Metaberine™ is an advanced, clinically proven Berberine ingredient formulated with Zeus Hygia’s proprietary BioSOLVE® technology—a 100% aqueous, eco-friendly green process that produces a highly uniform, porous powder with dramatically improved solubility and bioavailability.
Unlike conventional berberine extracts with less than 2% absorption, Metaberine™ achieves 9× higher bioavailability at just 200 mg/day versus the 500–1500 mg typically required—reducing dosage burden and eliminating gastric discomfort.
By modulating GLP-1 activity, activating the AMPK pathway, and supporting healthy lipid profiles, Metaberine™ delivers a comprehensive, natural alternative to expensive GLP-1 therapies for metabolic wellness and weight management.
“Metaberine™ is the most effective and thoroughly researched metabolic support available at the lowest daily dosage.”
— Dr. Arunkanth Krishnakumar, Co-founder & CEO, Zeus Hygia
Key Benefits
Five Pillars of Metabolic Wellness
The Science
Pharmacokinetic Superiority Proven
In a randomised, double-blind, placebo-controlled crossover trial with 36 participants, Metaberine™ demonstrated unmatched absorption and clinical outcomes versus standard berberine extract.
Clinical Outcomes — 14-Day Trial
36 participants · Double-blind · Placebo-controlled · Crossover design
- 8%
Reduction in fasting blood glucose levels
- 14%
Decrease in post-prandial glucose spikes
- 23%
Increase in GLP-1 secretion for appetite & weight control
- 2%
Reduction in LDL cholesterol levels
- 2.5%
Improvement in total cholesterol for a healthier lipid profile
Recommended Daily Dose
200 mg
vs 500–1500 mg
standard berberine
Watch & Learn
See Metaberine™
in Action
Discover how Zeus Hygia’s proprietary BioSOLVE® technology transforms berberine bioavailability—and why Metaberine® is redefining metabolic health support for the nutraceutical industry.
- BioSOLVE® Technology Explained
- Clinical Research & Key Findings
- GLP-1 Pathway & Metabolic Benefits
Applications
Flexible Formulation Formats
Metaberine™ integrates seamlessly across a wide range of product types, enabling B2B partners to launch innovative metabolic health solutions.
- Tablets
- Capsules
- Soft Gels
- Nutraceutical Powders
Manufacturing
Purity, Safety & Excellence
Produced in a GMP-certified and USFDA-registered facility aligned with ISO 9001:2015 standards—Metaberine™ exemplifies manufacturing excellence and quality assurance at every stage.
- GMP Certified
- ISO 9001:2015
- FSSAI Approved
- USFDA Registered
- Non-GMO Verified
- Vegan Certified
BRANDS POWERED BY METABERINE™
Trusted by Innovative Brands
Discover how leading brands are leveraging Metaberine™, our clinically studied and highly bioavailable berberine ingredient, to create differentiated products for blood sugar support, weight management, and metabolic wellness.
NUTRITUNES
GATACA
OAK AND ZEN
ZYRO LIFE
FAQ
Frequently Asked Questions
Metaberine™ is an advanced, clinically proven Berberine ingredient formulated with proprietary BioSOLVE® technology. It supports metabolic pathways by activating the AMPK enzyme, improving insulin sensitivity, and enhancing lipid metabolism—delivering superior results at just 200 mg/day.
Yes. Metaberine™ aids weight management by supporting fat metabolism, reducing cravings via GLP-1 modulation, and improving energy balance—helping the body utilize nutrients more efficiently.
Absolutely. Metaberine™ supports hormonal balance, improves insulin response, and promotes metabolic stability—making it particularly beneficial for individuals managing PCOS or metabolic disorders where insulin resistance is a key factor.
Metaberine™ enhances insulin sensitivity and supports balanced glucose levels by activating both AMPK and GLP-1 pathways, promoting efficient sugar uptake and metabolism at the cellular level for measurable clinical outcomes.
Unlike regular extracts with less than 2% absorption, Metaberine™ offers 9× higher bioavailability, 37× higher Cmax, and a Tmax of just 30 minutes versus 8 hours—delivering clinically proven results at a fraction of the standard dosage.
Metaberine™ is pharmacokinetically tested, GMP certified, and well-tolerated at 200 mg/day with no gastric irritation—addressing the most common side effect reported with high-dose conventional berberine supplements.
Metaberine® doesn’t just improve berberine’s absorption it provides a clinically validated, formulation-friendly, and cost-effective solution that enables brands to deliver the benefits of berberine at lower dosages without the manufacturing challenges often associated with liposomal systems like stability issues, lipid to active ratio, uniformity & flowability
Partner with Zeus Hygia
Bring Metaberine™ to your next metabolic health product. We support B2B partners across pharma, nutraceuticals, OTC, and functional food markets globally.
Approvals & Accreditations









